Researchers in Guwahti and Vellore achieve breakthrough in transforming skin cells into stem cells

Stem cells play a pivotal role in the intricate biological processes of the body by giving rise to specialized cell types that constitute various organs and tissues.

As per a statement released by IIT Guwahati, the researchers have discovered a novel approach to tap into the potential of stem cells, EastMojo reports.

This involves converting regular cells such as skin or blood cells into iPSCs, which can then be directed to develop into diverse adult cell types, offering a potential paradigm shift in medical treatments.

A significant advantage lies in their capacity to generate patient-specific cells that can be transplanted without the threat of immune rejection.

Expanding on the groundwork laid by Professor Shinya Yamanaka, the Nobel Laureate of 2012 for his pioneering work in demonstrating the conversion of mature cells into iPSCs through gene manipulation, the team has devised an integration-free methodology.

This approach entails the introduction of specific genes into skin cells, effectively reprogramming them into iPSCs.

The resultant iPSCs exhibit remarkable versatility and genetic stability, enabling them to differentiate into an array of bodily cell types while retaining their original genetic constitution.

Notably, these iPSCs have been established as free from bacterial contamination, underscoring their potential for secure clinical applications.

The implications of this achievement extend to therapeutic endeavors. iPSCs can be guided to assume distinct cell identities, holding promise for treating ailments such as diabetes, leukemia, Parkinson’s, Alzheimer’s, among others.

This collaborative effort between IIT Guwahati and CMC Vellore mirrors the Indian government’s endorsement of stem cell research. Beyond contributing to local research, this breakthrough fosters an environment for partnerships with both national and international institutions.

The research findings, authored by a team led by Dr. Rajkumar P. Thummer and featuring researchers from IIT-G and CMC Vellore, have been published in the prestigious journal "Stem Cell Research," reported EastMojo.