Five people are said to be critical, while around 8-10 people are in serious condition and 10-15 in fair condition, the department said on Saturday.
The incident took place on Santa Monica Boulevard.
In a statement, the LAFD said it is coordinating patient triage and transport at this time.
According to the Los Angeles City Fire Department, the vehicle rammed into a crowd of people waiting to enter a nightclub along a busy boulevard in Los Angeles.
Victims were transported to hospitals and trauma centres.
The majority of the victims were females as they were waiting to enter a nightclub when the Nissan Versa struck them, along with a taco truck and a valet stand.
However, paramedics found that one of the patients had a gunshot wound. People inside the nightclubs came out to help the victims.