The two deceased persons were identified as Mukka Nivesh, 20, from Huzurabad in Karimnagar district and Gautham, 19, from Shivunipally village in Jangaon district.
They met with a tragic end after a speeding unidentified vehicle rammed into the car they were travelling in near Phoenix city, sources told The Hindu.
Nivesh was a second-year computer science engineering student at the Arizona State University.
He was the grandson of well-known doctor Mukka Krishnamurthy, Telangana Today reported.
The Arizona Police have started investigating the incident.
The family members are now trying to bring back the body.